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Using this medicine by inhlation or injection can cause life-threatening side effects, overdose, or death. Do not crush, chew, or break an extended-release tablet.
You may be more likely to have a seizure (convulsions) if you take tramadol while you are using certain other medicines.
Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.