buy fioricet Fioricet acetaminophen butalbital Information from Drugs.com. Includes side effects, interactions, indications. Fioricet and Esgic are brand name drugs made from a combination of acetaminophen (325 mg), butalbital (a barbiturate, 50 mg), and caffeine (40 mg). Butalbital that is in Fioricet will make you feel more sleepy and unable to stand still. If you feel so, do not drive or do risky activities